|
KMID : 0608520080140010161
|
|
Korean Journal of Oriental Medicine
2008 Volume.14 No. 1 p.161 ~ p.171
|
|
|
The inhibitory effects of Soongijeseub-bang(順氣除濕方) on the obese-mice caused by high-fat diet
|
|
Lee Woo-yeol
Shin Hyun-Kyu
|
|
|
Abstract
|
|
|
|
Objective : In order to investigate the effects of Soongijeseub-bang(here in after referred to SJB) on the obese gene and obese inhibitory, C57BL/6 mice were induced by high fat diet. Methods : C57BL/6 mice were divided into three groups(normal, high fat diet with control, high fat diet with SJB extract) and fed for 15 weeks. And measured body weight change, the weight change of the adipocytes in body, the levels of ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, NEFA(non-esterified fat acid), glucose in serum and the expression of β3AR, leptin, and TNF-α gene in primary adipocytes and adipocytes tissue. Results : The following results were obtained in this study.1. SJB 500 ㎎/㎏ extract group showed significant decrease in final weight. 2. SJB 500 ㎎/㎏ extract group showed significant decrease in the amount of adipocyte in weight. 3. All experimental group showed significant decrease in ALT and AST levels. 4. All experimetal group did not show significant decrease in glucose and creatinine levels. 5. All experimental group showed significant decrease in total cholesterol, LDL-cholesterol, triglyceride and NEFA levels. HDL-cholesterol were increase significantly in SJB 500 ㎎/㎏ extract group. 6. SJB 500 ㎎/㎏ extract group showed significant decrease in leptin levels. 7. All experimental group showed significantly increased expressions of β3AR in primary adipose cell and 3T3-L1 cell, and those of leptin in primary adipose cell and 3T3-L1 cell were decreased significantly. SJB 100 ㎕/㎖ extract group showed significant decrease in the expression of TNF- α. 8. SJB 500 ㎎/㎏ extract group showed decrease in the size of adipocyte in adipocytes tissue. 9. All experimental group showed significant decrease in adipose vacuoles in liver tissue.
|
|
|
KEYWORD
|
|
|
Soongijeseub-bang(SJB), obese gene, obese inhibitory, adipocyte, liver tissue
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|
|